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Abstract
Scientists have extensively studied the mechanisms that orchestrate the growth and division of bacterial cells. Cells adapt their shape and dimensions in response to variations in the intracellular and extracellular environments by integrating information about the presence of nutrients or harmful agents in the decision to grow or divide. Filamentation is a process that occurs when rod-shaped cells stop dividing but continue to grow, thus producing elongated cells.1 Some cells can naturally grow as filamentous, while others only do so under stressful conditions.2 Here, we use mathematical modeling and computational simulations to evaluate a toxic agent’s intracellular concentration as a function of cell length. We show that filamentation can act as a strategy that promotes the resilience of a bacterial population under stressful environmental conditions.
Acknowledgements
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